Dr Vincent Jannin considers the advantages of delivering biologic medications, including glucagon-like peptide-1s, via oral delivery and discusses the technological strides being made towards enabling biologics to shift away from parenteral delivery. Biological therapies, more commonly referred to as biologics, have redefined the treatment landscape across multiple disease areas, from metabolic disorders to oncology. However, despite their clinical impact, the vast majority of biologics remain constrained to parenteral administration.1 This reliance on injection not only contributes to patient burden but also creates inefficiencies across healthcare delivery.